VISTABEL®/ BOTOX® injections, manufactured by Allergan (USA), are aimed at dynamic facial lines elimination and hyperhidrosis treatment
VISTABEL®/ BOTOX® is a medical solution, complex botulinum toxin type A, a peripherally long-acting muscle relaxant (myorelaxant).
VISTABEL®/ BOTOX® acts upon neuromuscular junctions helping muscles to relax in the areas of continual tension and wrinkle formation. The relaxation effect results in significant wrinkle smoothing and skin aligning. Besides, it eliminates the cause of mimic wrinkles appearing – the habit to contract different facial expression muscles.
Pharmacodynamics VISTABEL®/ BOTOX®
Clostridium botulinum toxin type А acts as an effective agent and inhibits the release of acetylcholine (it is an organic chemical that functions as a neurotransmitter — it sends signals to CNS) at the neuromuscular junction, what is followed by the weakening of muscles spasm in the area of injection.
The restoration of neurotransmission occurs gradually as new nerve endings are formed and develop contacts with a post-synaptic motor end-plate.
Indications for VISTABEL®/ BOTOX® use in aesthetic medicine
Temporal correction of dynamic wrinkles of the upper face (glabellar lines, forehead lines and canthal lines “crow’s feet”) in adults.
Indications for wrinkle lines correction of the upper face only VISTABEL®/ BOTOX®:
- Significant gravity ptosis of facial tissues
- Significant upper and lower eyelid hernias
VISTABEL®/ BOTOX® injection areas in the upper face
- Lateral canthal lines / “crow’s feet”
- Glabellar lines
- Forehead lines
- Vertical line between the eyebrows
The purpose of VISTABEL®/ BOTOX® injections during wrinkle correction in the upper face
The main purpose of VISTABEL®/ BOTOX® injections is the reduction of the quantity of big and small wrinkles with a relaxed facial expression, but not the complete elimination of facial muscle irritability. Thus, the results are evaluated on the basis of the skin state during relaxation.
The balance between the muscles lowering and raising eyebrows is maintained due to the fact that by weakening the action of one set of muscles and removing wrinkles VISTABEL®/ BOTOX® injections release antagonistic muscles. For this reason, it is so critical to maintain the balance and ensure harmonious facial expressions.
The layout pictures of the recommended injection schemes of VISTABEL®/ BOTOX® in the upper face
Indications for hyperhidrosis treatment (excessive sweating) by VISTABEL®/ BOTOX® solution
- Axillary hyperhidrosis – excessive sweating of gland coils in armpit areas
- Plantar hyperhidrosis – excessive sweating of gland coils in feet areas
- Palmar hyperhidrosis – excessive sweating of gland coils in hand palms areas
VISTABEL®/ BOTOX® injection areas in hyperhidrosis cases (excessive sweating)
- Hand palms
- Feet
- Armpits
Contraindications of VISTABEL®/ BOTOX®
- Known pre-existing hypersensitivity to any solution component
- An inflammatory process at the site of the intended injection(s)
- An acute stage of an infectious disease
- Neuropathic disorders
- The presence of a disease associated with impaired transmission of nerve impulses
- Hepatitis and other liver diseases
- Hemophilia
- The acute phase of infectious diseases
- Oncology
- Pregnancy, lactation
- Severe forms of diabetes mellitus
OVER-DOSAGE
Overdose symptoms may appear in some time after the injection. Patients with symptoms of botulinum toxin type A poisoning (general weakness, ptosis, diplopia, swallowing problem and speech disorders, or paresis of breathing muscles) are to be hospitalized.
WARNING AND PRECAUTIONS
- VISTABEL®/ BOTOX® should be used with precautions in the following cases:
Marked facial asymmetry, ptosis, dermatochalasis, deep scars, patients with dense skin, the absence of the evident smoothing of vertical mimic lines between the eyebrows because of mechanical skin stretching.
- Impact on driving and using moving machinery:
VISTABEL®/ BOTOX® usage may lead to asthenic reactions, muscular weakness, dizziness, and visual disturbance. In case of such symptoms, the driving of the vehicles or the use of moving machinery may be dangerous.
Preparation procedure before the injections of Vistabel®/ Botox®
Before the administration of Vistabel®/ Botox® injections, patients should avoid the use of antibiotics and alcohol. Please refrain from massage and other cosmetological procedures and treatments. To avoid the increased blood flow to the face please do not sleep on your stomach the day before the injection of Vistabel®/ Botox®.
Increased blood flow circulation in the area of injection may lead to premature botulinum toxin disintegration. Please follow the preparation recommendations for Vistabel®/ Botox®, injections to achieve the expected effect from this cosmetological procedure.
The rehabilitation period after the injection of Vistabel®/ Botox®
Please refrain from sauna visits, sun exposure, intensive sports activities within two weeks after the procedure. It is also recommended to exclude alcohol and food that retains fluid in the body (spicy, flour-based, sweet).
Vistabel®/ Botox® shall be stored and administered in special medical care institutions exceptionally.
Vistabel®/ Botox® shall not be given to the patient for storage.
The injection of Vistabel®/ Botox® should be administered on outpatient basis.
Important
- VISTABEL®/ BOTOX® solution injections should only be administered by physicians with appropriate qualification, having undergone special training and obtaining the licence from the manufacturer company Allergan.
- One of the main conditions of Vistabel® / Botox ® usage is its absolute freshness, therefore it is very important to observe storage rules. Unopened vials of Vistabel® / Botox® should be stored in a refrigerator compartment. Thermal exposure may lead to negative consequences: the weakening or complete vanishing of the drug properties.
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The drug vial should be opened immediately in front of the patient.
Every new vial of the drug should be used for one single patient treatment only during a single session and should be diluted immediately before administration. The unused solution remains should be disposed of. - It is important to know that the shelf life of VISTABEL ® / BOTOX ® in the diluted state is 2 hours.
About the manufacturing company of VISTABEL®/ BOTOX®
Has various trade names – BOTOX® Cosmetic, VISTABEL® and VISTABEX® – to meet requirements of regulatory bodies regarding the differentiation of cosmetological and therapeutic indications for the use.
The first observations about Botulinum Toxin Type A as a preparation relaxing muscles and, as a result, removing painful spastic manifestations were performed in the 50s. 30 years later, Botulinum Toxin Type A was started to be used in ophthalmology to treat squint. Then the ‘pleasant’ side effect of Botulinum Toxin Type A has been for the first time discovered, which became its primary target purpose afterwards – smoothing of wrinkles.
In 1989, American company Allergan was the first company started producing Botulinum Toxin Type A commercially. Since then, it has been one of the main methods to eliminate premature signs of skin aging.
