Plinest — skin bioreparation based on PDRN: a natural result created by the skin itself
PDRN Technology: Deep Skin Restoration at the Cellular Level
Plinest, Plinest Fast, Plinest Eye and Plinest Newest are advanced injectable treatments developed by the Italian company Mastelli for natural rejuvenation, regeneration, and improvement of skin quality.
These products are based on PDRN (polydeoxyribonucleotides) — active DNA molecules with powerful regenerative potential that stimulate the skin’s own renewal processes, promote collagen production, and support tissue repair at the cellular level.
This is not just an aesthetic treatment — it is a true improvement of skin quality from within.
The Plinest Product Line
- Plinest
An intensive bioreparative treatment for visible signs of ageing, loss of skin density, and reduced firmness.
Recommended for:
• moderate to deep wrinkles
• skin laxity
• decreased tissue density
• loss of facial contour definition
• age-related changes of the face, neck, and décolleté
Effects:
• visibly firmer, denser skin
• lifting effect
• wrinkle reduction
• improved facial contours
• increased elasticity
• restored skin tone
Composition:
• PDRN — 20 mg/ml
• physiological buffered solution
Syringe volume: 2 ml
- Plinest Fast
A delicate formula designed for younger skin, prevention of ageing, and sensitive areas.
Recommended for:
• first signs of ageing
• dryness and dehydration
• reduced skin tone
• thin skin
• under-eye area
• perioral area
Effects:
• intensive hydration
• radiant skin glow
• improved skin texture
• reduction of fine lines
• prevention of age-related changes
• fresh and well-cared-for appearance
Composition:
• PDRN — 7.5 mg/ml
• physiological buffered solution
Syringe volume: 2 ml
- Plinest Eye
A specialised bioreparative treatment for the delicate eye area.
Designed to correct age-related changes in the periorbital area without adding heaviness to the tissues.
Recommended for:
• dark circles under the eyes
• puffiness
• crow’s feet
• reduced eyelid tone
• thin, dry skin around the eyes
• tired-looking eyes
Effects:
• reduction of dark circles
• decreased puffiness
• strengthening of thin eyelid skin
• smoothing of fine wrinkles
• fresher, more open look
• improved skin quality around the eyes
Composition:
• PDRN
• physiological buffered solution
Syringe volume: 2 ml
- Plinest Newest
An innovative next-generation treatment combining PDRN with hyaluronic acid.
Ideal for intensive skin recovery, deep hydration, and anti-age therapy.
Recommended for:
• dehydrated skin
• dull complexion
• reduced firmness
• early and advanced signs of ageing
• wrinkles
• photoaging
• stressed and tired skin
• recovery after sun exposure or aggressive procedures
Effects:
• deep and long-lasting hydration
• visible skin radiance
• increased density and elasticity
• wrinkle reduction
• improved skin turgor
• fresher, rested appearance
• cumulative anti-age effect
Composition:
• PDRN
• hyaluronic acid
• physiological solution
Syringe volume: 2 ml
Origin and Composition of the Active Ingredient
The active base of these treatments is PDRN (polydeoxyribonucleotides) — highly purified DNA fragments with strong regenerative potential.
They are obtained from biological raw material derived from Rainbow trout (Oncorhynchus mykiss), known for its high level of biocompatibility with human tissues.
A multi-stage purification process is used during production, ensuring:
• removal of proteins and foreign impurities
• preservation of only active DNA fragments
• high purity and safety standards
The resulting biomaterial:
• is naturally accepted by the tissues
• does not trigger an immune response
• carries a minimal risk of allergy
Important: despite the common reference to “salmon DNA,” Plinest products specifically use trout-derived material.
How Does PDRN Work?
PDRN acts as a biostimulator, activating the skin’s own regenerative processes:
• stimulates fibroblast activity
• enhances collagen and elastin synthesis
• improves microcirculation
• accelerates tissue regeneration
• normalises hydration levels
As a result, the skin does not simply receive temporary hydration — it restores its own functions, density, elasticity, and healthy appearance.
What Results Can Be Expected?
• firmer, denser skin
• reduction of wrinkles
• smoother, fresher complexion
• healthy skin glow
• deep hydration
• reduced signs of fatigue
• improved skin texture
• natural rejuvenation without changing facial features
Indications
• age-related skin changes
• reduced tone and elasticity
• dryness and dehydration
• wrinkles of varying severity
• dull complexion
• photoaging
• recovery after laser procedures and peels
• post-acne marks
• scars and stretch marks
• hair loss
• eye area concerns
• stressed and tired skin
At What Age?
• Plinest Fast — usually from age 25
• Plinest Eye — at the first changes in the eye area
• Plinest — more commonly from age 30–35
• Plinest Newest — individually recommended for dry skin and early ageing signs
The choice of product depends not on age, but on the skin condition and the patient’s goals.
Treatment Course
• main course: 3–5 sessions
• interval: every 2–3 weeks
• eye area: 3–4 sessions every 10–14 days
• maintenance therapy: 1 session every 3–4 months
The exact treatment protocol is selected individually after consultation.
Contraindications
• pregnancy and breastfeeding
• inflammation in the injection area
• acute infections
• individual intolerance to ingredients
• autoimmune diseases
• oncological conditions
• damaged skin in the treatment area
• under 18 years of age
